Physiology Fundamentals

  • HMX
Physiology Course Illustration

Registration Deadline: June 2

Registration Deadline: July 14

Group Enrollment Option A program that is a popular choice for organizations and institutions to purchase in bulk.

Deadline Approaching Enroll now to secure your seat.

Build a body of knowledge on the systems that keep bodies functioning.

  • Online; Instructor-Paced

Lessons are released weekly and remain available until the course ends.

 

Available Start Dates

June 9

July 21

$1,025

Multi-course bundle pricing is also available across enrollment periods. The student price for an individual course is $800 and cannot be combined with course discounts.

Certificate

Earn a Certificate of Completion upon successfully completing all coursework.

10 Weeks, 4-6 Hours/Week

Most people can expect to spend around 40 hours total, but this depends on your baseline knowledge and how carefully you take notes.

  • Online; Instructor-Paced

Lessons are released weekly and remain available until the course ends.

 

Available Start Dates

June 9

July 21

$1,025

Multi-course bundle pricing is also available across enrollment periods. The student price for an individual course is $800 and cannot be combined with course discounts.

Certificate

Earn a Certificate of Completion upon successfully completing all coursework.

10 Weeks, 4-6 Hours/Week

Most people can expect to spend around 40 hours total, but this depends on your baseline knowledge and how carefully you take notes.

On This Page

Overview

Understanding how the body works is vital for effectively treating patients. This knowledge is essential for advancing medical science, developing new treatments, and improving health outcomes. 

In this foundational HMX course, you will learn essential principles underlying how the human body functions. Through engaging, online lessons, you will gain an understanding of how this knowledge comes into play in real-world scenarios and in clinical settings from the intensive care unit to the cardiac catheterization lab.

Learning Objectives

  • Understand how the body reacts to stimuli to maintain steady-state conditions
  • Learn fundamental concepts like partial pressure, flow through tubes, compliance, supply and demand, and acid-base balance and how they relate to the working of biological systems
  • See how basic principles apply in real world and clinical settings

Who Should Participate

Pre-med students; Current medical students; Health care professionals working in R&D, product management and strategy, sales, and marketing

Overview

Understanding how the body works is vital for effectively treating patients. This knowledge is essential for advancing medical science, developing new treatments, and improving health outcomes. 

In this foundational HMX course, you will learn essential principles underlying how the human body functions. Through engaging, online lessons, you will gain an understanding of how this knowledge comes into play in real-world scenarios and in clinical settings from the intensive care unit to the cardiac catheterization lab.

Learning Objectives

  • Understand how the body reacts to stimuli to maintain steady-state conditions
  • Learn fundamental concepts like partial pressure, flow through tubes, compliance, supply and demand, and acid-base balance and how they relate to the working of biological systems
  • See how basic principles apply in real world and clinical settings

Who Should Participate

Pre-med students; Current medical students; Health care professionals working in R&D, product management and strategy, sales, and marketing

Questions?

Have questions about HMX courses, enrollment, or learning options? Contact our team by email—we’re happy to assist.

About the Course

HMX online courses bring complex material to life through engaging biomedical visualizations, clinical applications, and true-to-life scenarios paired with lectures from Harvard Medical School faculty and leading experts. 

Who Should Enroll

This fundamentals course is appropriate for pre-med and current medical students interested in building their foundational knowledge of medical science, as well as professionals in health care and related fields who need a fundamental understanding of physiology – including those working in R&D, product management, strategy, sales, marketing, and other roles. 

Course Format

Most people can expect to spend around 40-60 hours total, but this depends on your baseline knowledge, how carefully you take notes, and how seriously you take the assessments. Lessons from the courses are released weekly and remain available until the courses end. The course wraps up with a final exam administered the final two days of the session. 

Additional Course Information

Overview

  • Course introduction
  • Meet the faculty
  • High-level overview

Partial Pressure

  • Partial pressure basics
  • Partial pressures in the lungs and blood

Movement of Body Fluids

  • Osmotic forces
  • Starling forces
  • Body fluid compartments
  • Osmotic forces in the kidney

Flow Through Tubes

  • Ohm’s Law analogy
  • Resistance – series vs. parallel
  • Laminar vs. turbulent flow
  • Air trapping

Compliance

  • Compliance basics
  • Surface tension
  • Laplace’s Law
  • Surface tension and alveoli
  • Elastic and surface forces in the lung

Supply and Demand

  • Aerobic vs. anaerobic metabolism
  • Oxygen delivery
  • Ohm’s Law application
  • Fick principle

Transmural Pressure

  • Transmural pressure basics
  • Flexible tubes
  • Cardiovascular applications
  • Respiratory applications

Dynamic and Steady State Conditions

  • Dynamic and steady state basics
  • Dynamic conditions
  • Pulmonary applications

Acid-Base

  • Acid-base physiology
  • Respiratory acid
  • Metabolic acid
  • Metabolic acid – elimination by kidney

Homeostasis

  • Homeostasis basics
  • Blood pressure
  • Acid-base applications

Exercise – Integration

  • Oxygen in exercise
  • Respiratory quotient
  • Anaerobic threshold

Extend Your Learning: Learn More, Save More

Whether you are building foundational medical science knowledge, preparing for advanced study, or expanding your understanding of the health care ecosystem, combining courses helps you connect concepts across disciplines while saving on enrollment.

You can bundle up to five HMX or HealthXcelerate courses. Bundle discounts apply to all courses selected. A bundle can consist of courses in the same upcoming enrollment period or the following enrollment period. 

Two-course bundle: 25% discount 
Three-course bundle: 30% discount 
Four-course bundle: 35% discount
Five-course bundle: 40% discount

View all bundle-eligible programs.

Frequently Asked Questions

Follow the link below for more information around payment and policies.

Physiology Fundamentals introduces how organ systems work together to maintain homeostasis, covering cardiovascular, respiratory, renal, and other key systems. It explains how normal physiological processes relate to disease mechanisms and clinical findings.

Highlights include clear, system‑based explanations, visualizations of organ function, and clinical correlations that link physiology to patient symptoms and treatments. The course builds a strong platform for further study in pathophysiology and pharmacology.

This foundational course is ideal for pre‑med and medical students, as well as health care professionals and industry staff who need a better understanding of how the body works in health and disease.

Physiology Fundamentals is right for you if you are preparing for or engaged in medical or health professions training, or if your work requires you to understand how organ systems function and fail. It is especially useful if you want to strengthen your base for courses in pathophysiology, pharmacology, or clinical medicine, or to better interpret clinical data and patient presentations.

Typical learners include pre‑med and medical students, nursing and allied health students, residents, and professionals from pharma, biotech, and medical device companies. Many have basic science coursework and are looking for a clinically oriented physiology refresher or foundation.

By completing this course, you’ll develop a clearer, integrated understanding of how major organ systems function and how physiological principles relate to clinical signs and symptoms. This can improve your readiness for advanced coursework and exams, enhance your clinical reasoning, and help you collaborate more effectively with clinical teams. The Harvard Medical School certificate also signals a strong physiology foundation to schools and employers.

Expertise in physiology is typically gained through advanced training such as an MD/DO, PhD, or master’s degree in physiology or related biomedical sciences, often combined with research or teaching focused on organ systems and disease mechanisms. Physiology Fundamentals provides a core, clinically relevant overview that supports success in those programs and in careers that rely on a deep understanding of human physiology.

Physiology Fundamentals runs online for 10 weeks in an instructor‑paced format, typically requiring 4–6 hours per week, plus a final exam at the end of the course.

Your progress throughout the course will determine your eligibility for a Certificate of Completion from Harvard Medical School. Earning a certificate requires significant effort; learners must complete all course material by the course end date in order to qualify.

You can bundle up to five courses. Bundle discounts apply to all courses selected. A bundle can consist of courses in the same upcoming enrollment period or the following enrollment period. Bundle-eligible courses include HMX and HealthXcelerate. 

Two-course bundle: 25% discount 
Three-course bundle: 30% discount 
Four-course bundle: 35% discount
Five-course bundle: 40% discount

View all bundle-eligible programs.

The student price for an individual course is $800. The student pricing discount is only available for foundational HMX courses and cannot be combined with course bundles

Limited program fee assistance is available for participants who qualify. To apply, please submit a request via the fee assistance request form or email learn@hms.harvard.edu for more information.

Group Enrollments

HMX courses are ideal for organizations looking to train teams or larger groups. Group pricing is available, making it a cost-effective investment in team development.

Faculty

HMX courses are led by Harvard Medical School faculty, working in collaboration with a multi-disciplinary team of experts in biomedical visualization, assessment, and the science of learning to create a unique learning experience that will stay with you.

Michael J. Parker, MD, Associate Dean for Online Learning / Faculty Director of HMX / Assistant Professor of Medicine, Harvard Medical School

Melanie Hoenig, MD, Associate Professor of Medicine, Harvard Medical School / Nephrologist, Beth Israel Deaconess Medical Center

Barbara LeVarge, MD, Instructor of Medicine, Harvard Medical School / Pulmonologist, Beth Israel Deaconess Medical Center (former)

Duane Pinto, MD, MPH, Associate Professor of Medicine, Harvard Medical School / Interventional Cardiologist, Beth Israel Deaconess Medical Center

HMX Faculty Perspectives

Why do you think it’s important for health care professionals to learn physiology?

"Physiology is truly the science of how the body works at a macro level. It helps us understand how all the organ systems are integrated and, when we are healthy, are seamlessly monitoring and responding to multiple unconscious inputs every moment of the day and night to keep us functioning well. It is also the foundation for studying and making sense of the impact of disease states, which invariably alter the normal physiology and lead to symptoms."  -Richard M. Schwartzstein, MD

View More HMX Faculty Perspectives

From Our Learners

Hear from HMX students as they share their experiences learning online with Harvard Medical School.

"The HMX course linked the basic knowledge with the clinical application. I have learned how these concepts are applied in real clinical scenarios."

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In order to comply with applicable U.S. export control and sanctions regulations, Harvard Medical School prohibits access to and use of Harvard Medical School educational offerings, programs and resources to individuals from certain sanctioned regions or who are otherwise subject to U.S. government sanctions, unless appropriate authorization is in place.

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