Biochemistry Fundamentals

  • HMX

-

Registration Deadline: August 26

Group Enrollment Option A program that is a popular choice for organizations and institutions to purchase in bulk.

Learn why human health is dependent on chemistry, and what that means for clinical care.

  • Online; Instructor-Paced

Lessons from the courses are released weekly and remain available until the courses end, so you can work at your own pace.

$1,025

Multi-course bundle pricing is also available. The student price for an individual course is $800 and cannot be combined with course bundles.

Certificate

There are two certification levels, based on participant scores: Certificate of Achievement; Certificate of Completion

10 Weeks, 4-6 Hours/Week

Most people can expect to spend around 40-60 hours total, but this depends on your baseline knowledge and how carefully you take notes.

On This Page

Overview

Understanding biochemistry is an excellent foundation for learning all of biology, but it can be difficult to make sense of the complexity of biochemical systems. 

In this foundational course, you will learn about the principles governing the interactions of individual molecules, and how those same principles apply at the scale of cells and organisms. Along the way, you will see how biochemistry intersects with human disease and clinical care. Engaging, interactive lessons will help you gain an in-depth understanding of biochemistry and equip you for future work in health care and related sectors. 

Learning Objectives

  • Understand fundamental principles of energy and thermodynamics, and the importance of enzymes in biochemical pathways
  • Learn about cellular specialization and how cell functions are explained by the chemical properties and structure of biological molecules
  • See how foundational concepts apply in real-life scenarios and clinical settings

Participant Types

Pre-med students; Current medical students; Health care professionals working in R&D, product management and strategy, sales, and marketing

About the Course

HMX online courses bring complex material to life through engaging biomedical visualizations, clinical applications, and true-to-life scenarios paired with lectures from Harvard Medical School faculty and leading experts. 

Who Should Apply

This foundational course is appropriate for pre-med and current medical students interested in building their foundational knowledge of medical science, as well as professionals in health care and related fields who need a fundamental understanding of biochemistry – including those working in R&D, product management, strategy, sales, marketing, and other roles. 

Course Format

Most people can expect to spend around 40-60 hours total, but this depends on your baseline knowledge, how carefully you take notes, and how seriously you take the assessments. Lessons from the courses are released weekly and remain available until the courses end, so you can work at your own pace. The course wraps up with a final exam administered the final two days of the session.

Additional Course Information

For information around payments and policies, please review our frequently asked questions.

Course Overview 

  • Course introduction
  • Meet the faculty

The Rules of Energy

  • Thermodynamics of chemical reactions
  • Equilibrium and Le Chatelier’s principle
  • The role of enzymes and enzyme regulation
  • Glycolysis

How Energy is Harnessed

  • Coupling chemical reactions
  • Energy currencies: ATP and NADH
  • The tricarboxylic acid cycle
  • The electron transport chain

How Energy is Transformed

  • Bypass reactions and catabolic pathways
  • Gluconeogenesis
  • Metabolic networks
  • Diet and energy

Cellular Specialization

  • Cellular metabolic specialization
  • The liver and muscle in carbohydrate metabolism
  • The role of adipose tissue in lipid metabolism
  • Diabetes

Compartmentalization of Biochemical Pathways

  • Membranes and organelles
  • Pumps and osmolarity
  • Sequestration of chemical reactions
  • Fatty acid synthesis and oxidation
  • The secretory pathway

Signaling Pathways

  • Response to stimuli
  • Receptors, ligands, and enzyme cascades
  • Positive and negative feedback
  • Endocrine signaling (insulin and glucagon)

The Chemistry of Life

  • The hydrophobic effect
  • Amino acid and protein structure
  • How structure dictates function
  • Inhibitors
  • Allosteric and covalent enzyme regulation

This foundational course is appropriate for any participants with a background in basic biology, chemistry, and physics who want an introduction to key subjects taught in medical school, and a look at how these concepts are applied in medical practice.

Your scores and participation in assessments throughout the course, including a final exam, will determine whether you qualify for a Certificate of Achievement or Certificate of Completion from Harvard Medical School. Earning a certificate requires significant effort, and not all participants will meet that level of achievement. You will not receive a letter grade (A, B, C, and so on). 

Are you ready to elevate your educational journey and maximize the investment in your future?

You can bundle up to five courses. Bundle discounts apply to all courses selected. All courses in a bundle must be completed during the following two enrollment periods.

Two-course bundle: 25% discount 
Three-course bundle: 30% discount 
Four-course bundle: 35% discount
Five-course bundle: 40% discount

View all bundle-eligible programs. 

The student price for an individual course is $800. The student pricing discount is only available for foundational HMX courses and cannot be combined with course bundles

Limited program fee assistance is available for participants who qualify. Please email learn@hms.harvard.edu for more information.

Group Enrollments

HMX courses are ideal for organizations looking to train teams or larger groups. Group pricing is available, making it a cost-effective investment in team development.

Faculty

HMX courses are led by Harvard Medical School faculty, working in collaboration with a multi-disciplinary team of experts in biomedical visualization, assessment, and the science of learning to create a unique learning experience that will stay with you.

Marie E. McDonnell, MD, Lecturer on Medicine, Harvard Medical School / Endocrinologist, Brigham and Women’s Hospital

Eli Miloslavsky, MD, Assistant Professor of Medicine, Harvard Medical School / Rheumatologist, Massachusetts General Hospital

HMX Faculty Perspectives

Why do you think it’s important for health care professionals to learn biochemistry?

"To be able to provide effective medical care to patients, health care professionals need to first understand how the human body functions in health and in disease. To truly gain this understanding, you need to master what happens at the smallest functional units of the body – the cells and the molecules within them – and how these small units aggregate into a functional human body. In a way, biochemistry is the core of medicine; health care providers rely on an understanding of biochemistry in most of their routine tasks."  -Ole-Petter (“OP”) Hamnvik, MB BCh BAO, MMSc

View More HMX Faculty Perspectives

From Our Learners

Hear from HMX students as they share their experiences learning online with Harvard Medical School.

"[This course] would be very helpful for students who are struggling with the concepts in class, mainly because the strength of the HMX program is that it explains difficult concepts in more easily understandable language."

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