Immunology Fundamentals

  • HMX

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Registration Deadline: August 26

Group Enrollment Option A program that is a popular choice for organizations and institutions to purchase in bulk.

Get an in-depth look at how the body fights disease – and how new therapies can help.

  • Online; Instructor-Paced

Lessons are released weekly and remain available until the course ends.

$1,025

Multi-course bundle pricing is also available. The student price for an individual course is $800 and cannot be combined with course bundles.

Certificate

There are two certification levels, based on participant scores: Certificate of Achievement; Certificate of Completion

10 Weeks, 4-6 Hours/Week

Most people can expect to spend around 40 hours total, but this depends on your baseline knowledge and how carefully you take notes.

On This Page

Overview

Microbial life forms are an ever-present, extremely dangerous threat to our survival, against which the immune system must constantly defend. Expanding knowledge of the immune system has led to recent medical advances, and an understanding of the basic concepts of immunology is now essential for anyone interested in health care. 

In this foundational HMX course, you will learn about the processes that enable our immune systems to respond to evolving threats, and learn about new, immunology-based disease treatments. Real-world applications will help you explore concepts, providing relevance and integration of key principles. 

Learning Objectives

  • Understand how the innate and adaptive immune systems function to protect the body from disease
  • Learn what happens when the immune system breaks down, leading to immunodeficiency and autoimmunity
  • See how key immunology concepts are linked to the treatment of disease, including through new therapies that harness the power of the immune system

Participant Types

Pre-med students; Current medical students; Health care professionals working in R&D, product management and strategy, sales, and marketing

About the Course

HMX online courses bring complex material to life through engaging biomedical visualizations, clinical applications, and true-to-life scenarios paired with lectures from Harvard Medical School faculty and leading experts. 

Who Should Apply

This foundational course is appropriate for pre-med and current medical students interested in building their foundational knowledge of medical science, as well as professionals in health care and related fields who need a fundamental understanding of immunology – including those working in R&D, product management, strategy, sales, marketing, and other roles. 

Course Format

Most people can expect to spend around 40-60 hours total, but this depends on your baseline knowledge, how carefully you take notes, and how seriously you take the assessments. Lessons from the courses are released weekly and remain available until the courses end, so you can work at your own pace. The course wraps up with a final exam administered the final two days of the session. 

Additional Course Information

For information around payments and policies, please review our frequently asked questions.

Overview
Course introduction
Meet the faculty
Basic terms and concepts

Innate Immunity and Inflammation
Sentinel cells and circulating leukocytes
Inflammatory events and signaling
The formation of pus

Microbial Recognition and Responses in Innate Immunity
Pattern recognition receptors
Innate immune signaling
The antiviral state
The complement system

Antibodies – Structure and Function
B lymphocytes
Antibody structure and function
How antibodies can cause disease

Lymphocyte Development and Diversity
Lymphocyte development
Clonal selection and expansion
Differences between B and T lymphocytes
The generation of lymphocyte receptor diversity

T Cell Activation by Antigens
The role of dendritic cells
The lymphatic system and delivery of antigen to lymph nodes
Adaptive immune activation in secondary lymphoid tissues
Costimulation and inhibitory signaling
Antigen presentation

T Cell-Dependent B Cell Responses
T Cell activation of B cells
The germinal center reaction
Isotype switching and affinity maturation

Helper T Cells
Helper T cell functions
Helper T cell subsets
The role of helper T cells in disease

Cytotoxic T Cells
Cytotoxic T cell functions
Selection and expansion of cytotoxic T cells
Contraction and memory
Therapies that target cytotoxic T cell functions

Failures of the Immune System
Immunodeficiencies
Mechanisms of tolerance and loss of self-tolerance
Autoimmune diseases
Allergic diseases

Immunology-Based Therapy of Diseases
Transplantation and transfusion
Vectored immunoprophylaxis and chimeric antigen receptor T cells
Neoantigen discovery and checkpoint blockade

These are appropriate for any participants with a background in basic biology, chemistry, and physics who want an introduction to key subjects taught in medical school, and a look at how these concepts are applied in medical practice.

Your scores and participation in assessments throughout the course, including a final exam, will determine whether you qualify for a Certificate of Achievement or Certificate of Completion from Harvard Medical School. Earning a certificate requires significant effort, and not all participants will meet that level of achievement. You will not receive a letter grade (A, B, C, and so on). 

Are you ready to elevate your educational journey and maximize the investment in your future?

You can bundle up to five HMX fundamental or advanced courses. Bundle discounts apply to all courses selected. All courses in a bundle must be completed during the following two enrollment periods.

Two-course bundle: 25% discount 
Three-course bundle: 30% discount 
Four-course bundle: 35% discount
Five-course bundle: 40% discount

View all bundle-eligible programs. 

The student price for an individual course is $800. The student pricing discount is only available for foundational HMX courses and cannot be combined with course bundles

Limited program fee assistance is available for participants who qualify. Please email learn@hms.harvard.edu for more information.

Group Enrollments

HMX courses are ideal for organizations looking to train teams or larger groups. Group pricing is available, making it a cost-effective investment in team development.

Faculty

HMX courses are led by Harvard Medical School faculty, working in collaboration with a multi-disciplinary team of experts in biomedical visualization, assessment, and the science of learning to create a unique learning experience that will stay with you.

Jules Dienstag, MD, Carl W. Walter Professor of Medicine, Harvard Medical School / Gastroenterologist, Massachusetts General Hospital

Keith Flaherty, MD, Professor of Medicine, Harvard Medical School / Hematologist/ Oncologist, Massachusetts General Hospital

Joseph Merola, MD, MMSc, Associate Professor, Harvard Medical School / Dermatologist, Brigham and Women’s Hospital

David Sloane, MD, Instructor, Harvard Medical School / Allergist and Immunologist, Brigham and Women’s Hospital

HMX Faculty Perspectives

Why do you think it’s important for health care professionals to learn immunology?

"The immune system protects us from infections and cancer in a very exquisitely precise way. Most human diseases result from some loss of this precision. Sometimes the immune system is overwhelmed by an infection or a tumor. On other occasions the immune system aberrantly or over-exuberantly responds to innocuous environmental molecules or microbes – or to self-structures – and this results in a loss of immune regulation that results in disease. Understanding immunology has allowed the prevention of infections by the use of vaccines, has helped the medical world develop the ability to transfuse blood making modern surgery possible, has allowed transplantation to become a reality, and has led to rational treatments for allergies and autoimmune diseases, and what are likely the first real cures for cancer."  -Shiv Pillai, MD, PhD

View More HMX Faculty Perspectives

From Our Learners

Hear from HMX students as they share their experiences learning online with Harvard Medical School.

"[This course] helped me to better understand the basic sciences; studying it in advance is a great help to medical students."

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