Drug Discovery: Approaches to Discovering and Designing Different Therapeutic Modalities

  • HMX

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Registration Deadline: August 26

Group Enrollment Option A program that is a popular choice for organizations and institutions to purchase in bulk.

Learn how various therapeutic modalities are discovered.

  • Online; Instructor-Paced

Lessons are released weekly and remain available until the course ends.

$1,025

Enroll early to receive 10% off. Multi-course bundle pricing is also available. 

Early Registration Deadline:

Certificate

There are two certification levels, based on participant scores: Certificate of Achievement; Certificate of Completion

10 Weeks, 1-2 Hours/Week

Most people can expect to spend around 15–20 hours total, but this depends on your baseline knowledge and how carefully you take notes.

On This Page

Overview

The field of drug discovery and development is multifaceted and evolving quickly, allowing researchers to continually expand their toolkit of therapeutic modalities to treat and manage diseases. Learning about the advances in drug discovery has important implications for anyone working in health care and related sectors. 

In this engaging, online course, you will build on foundational knowledge of pharmacology to explore the latest advances in drug discovery. Experience an in-depth exploration of the discovery processes for various therapeutic modalities, including small molecules, proteins, nucleic acids, and cells during this advanced HMX course. You will gain insight into both standard and advanced methodologies used in the discovery, design, and preclinical development of current and novel therapeutics. 

Learning Objectives

  • Learn about the fundamental steps and considerations involved in the discovery process of various drug modalities
  • Explore examples of discovery of various therapeutics
  • Understand how the novel therapeutic approaches allow for improvement of existing treatments and expand the range of diseases that can be effectively treated

Participant Types

Pharmaceutical professionals or researchers; professionals in related sectors; health care professionals

About the Course

HMX online courses bring complex material to life through engaging biomedical visualizations, clinical applications, and true-to-life scenarios paired with lectures from Harvard Medical School faculty and leading experts. 

Who Should Apply

This advanced course is appropriate for professionals in the pharmaceutical industry or a related field seeking a comprehensive understanding of the discovery processes for both current and cutting-edge therapeutic modalities; health care professionals or researcher looking to expand your knowledge of diverse drug modalities and their discovery processes; learners familiar with the basics of drug discovery and eager to delve into advanced and specialized therapeutic approaches.

Course Format

Most people can expect to spend around 15–20 hours total, but this depends on your baseline knowledge, how carefully you take notes, and how seriously you take the assessments. Lessons from the courses are released toward the beginning of the course session and remain available until the courses end, so you can work at your own pace. There is a final exam at the end of each course that can be taken at any time during the multi-week final exam period. The flexible course format makes this an ideal choice for working professionals.

Additional Course Information

For information around payments and policies, please review our frequently asked questions.

Overview of Drug Discovery

  • The Promise of Drug Discovery

Discovery of Small Molecule Drugs

  • In Focus: How TPP and IND Guide and Frame Drug Discovery
  • Hit Identification
  • Hit Validation
  • Structure-Activity Relationship Studies
  • Parallel Medicinal Chemistry
  • Lead Optimization
  • Clinical Candidate Discovery
  • In Focus: Spectroscopy Methods
  • Clinical Linkage: Discovery of Small Molecule Protein Degraders

Discovery of Biologics and Nucleic Acid Therapeutics

  • Naturally Occurring Proteins
  • Step-by-Step: Protein Purification
  • Discovery of Monoclonal Antibodies
  • In Focus: Phage Display
  • Pharmacokinetics of Protein Therapeutics
  • Creative Proteins
  • Overview of Nucleic Acid Therapeutics
  • Discovery of siRNA Therapeutics
  • Discovery of PMO Exon Skippers
  • Discovery of mRNA Therapeutics
  • Clinical Linkage: Discovery of Protein and Nucleic Acid Therapeutics

Discovery of Cell Therapies

  • Background
  • Toolkit
  • Cell Modifications
  • Toxicology and Specifications Unique to Cell Therapies
  • Measuring Bioactivity in a Pre-clinical Setting
  • Ongoing Challenges
  • Clinical Linkage: Cell Therapy Manufacturing

Wrap-up

  • The Future of Drug Discovery

We recommend knowledge of basic chemistry, biology, and physics, as well as knowledge of key pharmacology concepts. This is an advanced course; for those who require more background in pharmacology, we offer Pharmacology: Essentials

Your scores and participation in assessments throughout the course, including a final exam, will determine whether you qualify for a Certificate of Achievement or Certificate of Completion from Harvard Medical School. Earning a certificate requires significant effort, and not all participants will meet that level of achievement. You will not receive a letter grade (A, B, C, and so on). 

Are you ready to elevate your educational journey and maximize the investment in your future?

You can bundle up to five courses. Bundle discounts apply to all courses selected. All courses in a bundle must be completed during the following two enrollment periods.

Two-course bundle: 25% discount 
Three-course bundle: 30% discount 
Four-course bundle: 35% discount
Five-course bundle: 40% discount

View all bundle-eligible programs. 

Group Enrollments

HMX courses are ideal for organizations looking to train teams or larger groups. Group pricing is available, making it a cost-effective investment in team development.

Faculty

HMX courses are led by Harvard Medical School faculty, working in collaboration with a multi-disciplinary team of experts in biomedical visualization, assessment, and the science of learning to create a unique learning experience that will stay with you.

David Avigan, MD, Theodore W. and Evelyn G. Berenson Professor of Medicine, Harvard Medical School / Cancer Center Director, Senior Vice President of Cancer Services, and Chief of Division of Hematology and Hematologic Malignancies, Beth Israel Deaconess Medical Center

Felicia Ciuculescu, MD, Tech Transfer Director, Cell Manipulation Core Facility, Dana-Farber Cancer Institute

John Diener, PhD, Senior Vice President, Tectonic

Benjamin Ebert, MD, PhD, George P. Canellos, MD, and Jean S. Canellos Professor of Medicine, Harvard Medical School / Chair of Medical Oncology, Dana-Farber Cancer Institute

Anastasia Khvorova, PhD, Professor, RNA Therapeutics Institute, UMass Chan Medical School / Director-at-large/Scientific & Research Council Chair, American Society of Gene and Cell Therapy

Milka Kostic, PhD, Lecturer, Biological Chemistry and Chemical Biology, Harvard Medical School / Director, Chemical Biology Program, Dana-Farber Cancer Institute

Sarah Nikiforow, MD, PhD, Assistant Professor of Medicine, Harvard Medical School / Technical Director, Immune Effector Cell Therapy Program and Medical Director, Connell and O’Reilly Families Cell Manipulation Core Facility, Dana-Farber Cancer Institute / Clinical Instructor of Medicine, Dana-Farber Cancer Institute

Carl Novina, MD, PhD, Associate Professor of Medicine, Harvard Medical School / Principal Investigator, Cancer Immunology and Virology, Dana-Farber Cancer Institute / Founder, Microbial Machines / Founder, Dynamic Cell Therapies, Inc.

Pamela Silver, PhD, Elliott T. and Onie H. Adams Professor of Biochemistry and Systems Biology, Harvard Medical School

Course Quiz

Are you ready for an advanced course? We recommend knowledge of basic chemistry, biology, and physics, as well as knowledge of key pharmacology concepts. Gauge your knowledge of pharmacology by taking this short quiz.

From Our Learners

Hear from HMX students as they share their experiences learning online with Harvard Medical School.

"During the courses, you are exposed to an umbrella of topics that convey a much bigger learning experience, ensuring key elements are covered and well understood."

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