Dana-Farber Center for BRCA & Related Genes Scientific Symposium
- Continuing Education

Explore the latest advances in hereditary cancer research and care at the Dana-Farber Center for BRCA and Related Genes Scientific Symposium, designed for clinicians and researchers to deepen knowledge of detection, treatment, and ethical issues in BRCA-associated cancers across multiple tumor types.
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Overview
Dana-Farber Cancer Institute Center for BRCA and Related Genes Scientific Symposium is for clinicians, researchers, and anyone interested in learning more about BRCA 1/2 and related genes and exploring the latest research in a variety of cancer types affected by the mutations in the BRCA pathway.
Learning Objectives
- Identify current and emerging approaches to early detection, screening, and prevention of hereditary breast, ovarian, pancreatic, and prostate cancers associated with mutations in the BRCA pathway.
- Recognize and analyze the latest clinical and translational discoveries in the treatment of breast, ovarian, pancreatic, and prostate cancers associated with hereditary or acquired mutations in BRCA1/2 and related genes.
- Discuss current ethical, legal, social as well as diversity and inclusion issues related to carriers of BRCA1/2 and related genes.
Developed and Offered By:
Continuing Education courses are developed by faculty from Harvard Medical School's teaching hospitals and accredited by Harvard Medical School. This course is offered by Dana-Farber Cancer Institute.
Schedule
All agenda sessions are in Eastern Time.
Tuesday, November 11, 2025
Registration and Opening Remarks
Panos Konstantinopoulos
8:00-8:30 am
Systemic therapy in homologous recombination deficient breast cancer
Susan Domchek; Alan D'Andrea
8:30-9:30 am
Aging as a Common Path to Breast Cancer Risk
Alan D'Andrea; Mark Labarge
9:30-10:15 am
Break
10:15-10:30 am
Ovarian cancer and early drug development
Stephanie Lheureux
10:30-11:15 am
Tuvusertib (ATRi)-based combinations to overcome PARP inhibitor resistance: early clinical experience
Alan D'Andrea; Ioannis Gounaris
11:15 am-12:00 pm
Lunch
12:00-1:00 pm
Rational DDR inhibitor combinations with immunotherapy and ADCs
Geoffrey Shapiro; Panos Konstantinopoulos
1:00-1:45 pm
Breast cancer in young BRCA carriers: The experience of the BRCA BCY collaboration
Geoffrey Shapiro; Matteo Lambertini
1:45-2:30 pm
PARP-inhibitor resistance – Beyond reversion mutations
Gerburg Wulf
2:30-3:15 pm
Break
3:15-3:30 pm
Nucleotide excision repair (NER) deficiency as a synthetic lethal target in solid tumors
Kent Mouw; Geoffrey Shapiro
3:30-4:15 pm
DNA damage and repair
Geoffrey Shapiro; Gaorav Gupta
4:15-5:00 pm
Closing Remarks
Panos Konstantinopoulos
5:00-5:15 pm
Faculty
Judy Garber, MD, MPH
Course Director
- Professor of Medicine, Harvard Medical School
- Co-Director, Center for BRCA and Related Genes
Panagiotis Konstantinopoulos
Course Director
- Associate Professor, Harvard Medical School
- Director, Center for BRCA and Related Genes
Dipanjan Chowdhury
Course Director
- Professor of Radiation Oncology, Harvard Medical School
- Co-Director, Center for BRCA and Related Genes
Alan D'Andrea
Course Director
- Director, Center for DNA Damage and Repair, Dana-Farber Cancer Institute
- Director, Susan F. Smith Center for Women’s Cancers, Dana-Farber Cancer Institute
- Director of Research, Mellen and Eisenson Family Center for BRCA and Related Genes, Dana-Farber Cancer Institute
- Alvan T. and Viola D. Fuller-American Cancer Society Professor of Radiation Oncology, Harvard Medical School
Brittany Bychkovsky, MD, MSc
Assistant Professor of Medicine, Harvard Medical School
Susan Domchek, MD
Director, Cancer Risk Evaluation Program, Abramson Cancer Center, University of Pennsylvania
Senior Fellow, Leonard Davis Institute of Health Economics, University of Pennsylvania
Executive Director, Basser Center for BRCA
Ioannis Gounaris, MD, PhD
VP, Head of Clinical Development DNA Damage Response (DDR), Merck
Gaorav Gupta, MD, PhD
Assistant Professor of Radiation Oncology, University of North Carolina Chapel Hill
Mark Labarge, PhD
Professor
Department of Population Sciences
Director, Postdoctoral Training Program
Deputy Director, Center for Cancer and Aging
Beckman Research Institute at City of Hope
Matteo Lambertini, MD, PhD
Associate Professor, University of Genova
Stephanie Lheureux, MD, PhD
Clinician Investigator, Princess Margaret Cancer Centre
Cancer Clinical Research Unit (CCRU), Princess Margaret Cancer Centre
Kent Mouw, MD, PhD
Assistant Professor of Radiation Oncology, Harvard Medical School
Co-Director, Bladder Cancer Center
Geoffrey Shapiro, MD, PhD
Senior Vice President, Developmental Therapeutics, Dana-Farber Cancer Institute
Gerburg Wulf, MD
Associate Professor, Medicine, Harvard Medical School
Active Staff, Hematology/Oncology, Beth Israel Deaconess Medical Center
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Course Fees
Fee Disclaimer
You may register through our secure online environment and will receive an email confirmation upon receipt of your payment.
Role | Standard Price |
---|---|
Physician (MD/DO) | Free |
Nurse (RN/APRN) | Free |
Psychologist | Free |
Resident/Fellow | Free |
Social Worker | Free |
Allied Health Professional / Other | Free |