Day 1
Tuesday, November 11, 2025
Registration and Opening Remarks
Panos Konstantinopoulos
8:00-8:30 am
Systemic therapy in homologous recombination deficient breast cancer
Susan Domchek; Alan D'Andrea
8:30-9:30 am
Aging as a Common Path to Breast Cancer Risk
Alan D'Andrea; Mark Labarge
9:30-10:15 am
Break
10:15-10:30 am
Ovarian cancer and early drug development
Stephanie Lheureux
10:30-11:15 am
Tuvusertib (ATRi)-based combinations to overcome PARP inhibitor resistance: early clinical experience
Alan D'Andrea; Ioannis Gounaris
11:15 am-12:00 pm
Lunch
12:00-1:00 pm
Rational DDR inhibitor combinations with immunotherapy and ADCs
Geoffrey Shapiro; Panos Konstantinopoulos
1:00-1:45 pm
Breast cancer in young BRCA carriers: The experience of the BRCA BCY collaboration
Geoffrey Shapiro; Matteo Lambertini
1:45-2:30 pm
PARP-inhibitor resistance – Beyond reversion mutations
Gerburg Wulf
2:30-3:15 pm
Break
3:15-3:30 pm
Nucleotide excision repair (NER) deficiency as a synthetic lethal target in solid tumors
Kent Mouw; Geoffrey Shapiro
3:30-4:15 pm
DNA damage and repair
Geoffrey Shapiro; Gaorav Gupta
4:15-5:00 pm
Closing Remarks
Panos Konstantinopoulos
5:00-5:15 pm