Tuesday, November 11, 2025
Registration and Opening Remarks
Panos Konstantinopoulos
8:00-8:30 am
Systemic Therapy in Homologous Recombination Deficient Breast Cancer
Susan Domchek
8:30-9:30 am
Aging as a Common Path to Breast Cancer Risk
Mark Labarge
9:30-10:15 am
Break
10:15-10:30 am
The BRCA carrier journey: Integrating prevention and precision care
Stephanie Lheureux
10:30-11:15 am
Break
11:15-11:45 am
Tuvusertib (ATRi)-based Combinations to Overcome PARP Inhibitor Resistance: Early Clinical Experience
Ioannis Gounaris
11:45 am-12:30 pm
Lunch
12:30-1:30 pm
Rational DDR Inhibitor Combinations with Immunotherapy and ADCs
Panos Konstantinopoulos
1:30-2:15 pm
Breast Cancer in Young BRCA Carriers: The Experience of the BRCA BCY Collaboration
Matteo Lambertini
2:15-3:00 pm
PARP-inhibitor Resistance – Beyond Reversion Mutations
Gerburg Wulf
3:00-3:45 pm
Break
3:45-4:00 pm
Nucleotide Excision Repair (NER) Deficiency as a Synthetic Lethal Target in Solid Tumors
Kent Mouw
4:00-4:45 pm
Mechanisms that drive polymerase theta essentiality
Gaorav Gupta
4:45-5:30 pm
Closing Remarks
Panos Konstantinopoulos
5:30-5:40 pm