Day 1
Tuesday, November 11, 2025
Registration and Opening Remarks
Panos Konstantinopoulos
8:00-8:30 am
Systemic Therapy in Homologous Recombination Deficient Breast Cancer
Susan Domchek
8:30-9:30 am
Aging as a Common Path to Breast Cancer Risk
Mark Labarge
9:30-10:15 am
Break
10:15-10:30 am
Ovarian Cancer and Early Drug Development
Stephanie Lheureux
10:30-11:15 am
Tuvusertib (ATRi)-based Combinations to Overcome PARP Inhibitor Resistance: Early Clinical Experience
Ioannis Gounaris
11:15 am-12:00 pm
Lunch
12:00-1:00 pm
Rational DDR Inhibitor Combinations with Immunotherapy and ADCs
Panos Konstantinopoulos
1:00-1:45 pm
Breast Cancer in Young BRCA Carriers: The Experience of the BRCA BCY Collaboration
Matteo Lambertini
1:45-2:30 pm
PARP-inhibitor Resistance – Beyond Reversion Mutations
Gerburg Wulf
2:30-3:15 pm
Break
3:15-3:30 pm
Nucleotide Excision Repair (NER) Deficiency as a Synthetic Lethal Target in Solid Tumors
Kent Mouw
3:30-4:15 pm
DNA Damage and Repair
Gaorav Gupta
4:15-5:00 pm
Closing Remarks
Panos Konstantinopoulos
5:00-5:10 pm