New Evidence For How Lithium Affects Alzheimer’s Pathology in the Brain

In this episode of Science Snapshot, learn how amyloid plaques may trap lithium, lowering it in parts of the brain tied to memory, and how a low dose of lithium orotate reduced Alzheimer pathology and improved memory in mouse models.

Science snapshot lithium

One of the hallmarks of Alzheimer disease pathology is the presence of amyloid plaques in the brain, but their function has generally been poorly understood. Now, new evidence suggests that these plaques may trap lithium, leading to lower lithium levels in memory-related brain regions. In Alzheimer’s mouse models, low-dose lithium orotate reduced Alzheimer pathology and improved memory. 

 

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